A label-free electrochemical aptasensor based on platinum@palladium nanoparticles decorated with hemin-reduced graphene oxide as a signal amplifier for glypican-3 determination
Guiyin Li, Wenzhan Li, Shengnan Li, Xin‐Hao Li, Xiaoqing Yao, Wen Xue, Jintao Liang, Jiejing Chen, Zhide Zhou
Abstract
) and good selectivity. Furthermore, the fabricated aptasensor was applied to GPC3 determination in human serum samples with satisfactory recoveries of 94.3%-119% and RSDs of 0.15%-5.78%. The current work provides a flexible approach for the rapid and sensitive analysis of GPC3 and has a broad application prospect in the diagnosis of HCC.
Topics & Concepts
GrapheneDifferential pulse voltammetryAptamerDetection limitPlatinumNanoprobeHeminElectrochemistryPlatinum nanoparticlesElectrodeChemistryPalladiumOxideMaterials scienceCyclic voltammetryNanoparticleCombinatorial chemistryNanotechnologyChromatographyOrganic chemistryBiologyGeneticsPhysical chemistryHemeCatalysisEnzymeAdvanced biosensing and bioanalysis techniquesAnalytical Chemistry and SensorsElectrochemical sensors and biosensors