Metal-free cascade O–H double insertion between I(III)/S(VI)-ylides, carboxylic acids, and alcohols: modular access to unsymmetrical α,α-O,O-substituted ketones

Jiaohang Wei, Wen‐Xuan Zou, Qiong Hu, Mei-Zhu Bao, Dan‐Ting Shen, Lin Xiao, Jia‐Lin Song, Xiang Liu, Shang‐Shi Zhang

2024Organic Chemistry Frontiers17 citationsDOI

Abstract

Herein, we present a cascade O–H double insertion reaction between I (III) /S (VI) -ylides, carboxylic acids, and alcohols under metal-free conditions, enabling the modular synthesis of unsymmetrical α,α- O , O -substituted ketones.

Topics & Concepts

ChemistryMetalCascadeMedicinal chemistryAlcoholOrganic chemistryChromatographyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms

Metal-free cascade O–H double insertion between I<sup>(III)</sup>/S<sup>(VI)</sup>-ylides, carboxylic acids, and alcohols: modular access to unsymmetrical α,α-<i>O</i>,<i>O</i>-substituted ketones

Abstract

Topics & Concepts