Litcius/Paper detail

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

Sukhvinder Singh, Pawan Kumar Singh, Alokkumar Jha, Poonam Naik, Joveeta Joseph, Shailendra Giri, Ashok Kumar

2021Cell Reports Medicine67 citationsDOIOpen Access PDF

Abstract

/itaconate axis is a regulator of intraocular inflammation and provides evidence for using itaconate, along with antibiotics, to treat bacterial infections.

Topics & Concepts

InflammationAntibioticsImmune systemInflammasomeBiologyTranscriptomeStaphylococcus aureusMetaboliteEndophthalmitisImmunologyBacteriaMicrobiologyGeneGene expressionBiochemistryGeneticsImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsOcular Diseases and Behçet’s Syndrome