Using hyperpolarized <sup>129</sup>Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity
Ziyi Wang, Leith Rankine, Elianna Bier, David Mummy, Junlan Lu, Alex Church, Robert M. Tighe, Aparna Swaminathan, Yuh‐Chin T. Huang, Loretta G. Que, Joseph Mammarappallil, Sudarshan Rajagopal, Bastiaan Driehuys
Abstract
The diffusing capacity for carbon monoxide (DL CO ) is perhaps one of the most comprehensive physiological measures used in pulmonary medicine. Here, we spatially resolve and estimate its key components—accessible alveolar volume, membrane, and capillary blood volume conductances—using hyperpolarized 129 Xe MRI of ventilation, interstitial barrier uptake, and red blood cell transfer. This image-derived DL CO correlates strongly with measured values in 142 subjects with a broad range of pulmonary disorders.
Topics & Concepts
Diffusing capacityPulmonary Diffusing CapacityChemistryVolume (thermodynamics)Carbon monoxideXenonCapillary actionNuclear magnetic resonanceLungMedicineInternal medicineThermodynamicsPhysicsCatalysisLung functionOrganic chemistryBiochemistryAtomic and Subatomic Physics ResearchAdvanced MRI Techniques and ApplicationsQuantum, superfluid, helium dynamics