Synthesis of α-Alkylated Ketones via Selective Epoxide Opening/Alkylation Reactions with Primary Alcohols
Sertaç Genç, Süleyman Gülcemal, Salih Günnaz, Bekır Çetınkaya, Derya Gülcemal
Abstract
A new method for converting terminal epoxides and primary alcohols into α-alkylated ketones under borrowing hydrogen conditions is reported. The procedure involves a one-pot epoxide ring opening and alkylation via primary alcohols in the presence of an N-heterocyclic carbene iridium(I) catalyst, under aerobic conditions, with water as the side product.
Topics & Concepts
AlkylationChemistryPrimary (astronomy)EpoxideCatalysisIridiumCarbeneOrganic chemistryRing (chemistry)Combinatorial chemistryPhysicsAstronomyAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysisChemical Synthesis and Analysis