Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors
Jian Yao, Yudong Yin, Ho Jae Han, Shaoting Chen, Yuxiang Zheng, Benji Liang, Mengyue Wu, Kangqi Shu, Bikash Debnath, David B. Lombard, Quande Wang, Keguang Cheng, Nouri Neamati, Yanghan Liu
Topics & Concepts
ChemistryNAD+ kinasePyrazoloneIC50PotencyEnzymeBiochemistryLead compoundLysineSmall moleculeStereochemistryCombinatorial chemistryIn vitroAmino acidSirtuins and Resveratrol in MedicineCalcium signaling and nucleotide metabolismPARP inhibition in cancer therapy