Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease
Xin Lü, Nan Qin, Yijun Liu, Chenxi Du, Feng Feng, Wenyuan Liu, Yao Chen, Haopeng Sun
Topics & Concepts
ButyrylcholinesteraseChemistryCholinesterasePharmacologyIn vivoNeuroprotectionTertiary amineNeurotoxicityIn vitroBiochemistryEnzymeAcetylcholinesteraseAchéToxicityOrganic chemistryBiologyBiotechnologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsMedicinal Plants and Neuroprotection