Screening for <i>in-vivo</i> regional contractile defaults to predict the delayed Doxorubicin Cardiotoxicity in Juvenile Rat
Nourdine Chakouri, Charlotte Farah, Stéfan Matecki, Pascal Amédro, Marie Vincenti, Laure Saumet, Laurence Vergely, Nicolas Sirvent, Alain Lacampagne, Olivier Cazorla
Abstract
Our data suggest that screening of the contractile defaults of the base of the heart by regional 2D strain echocardiography is useful to detect subclinical myocardial dysfunction prior to the development of delayed anthracycline-induced cardiomyopathy in pediatric onco-cardiology.
Topics & Concepts
CardiotoxicityDoxorubicinMedicineAnthracyclineHeart failureIn vivoEjection fractionInternal medicineCardiologyDexrazoxaneCardiac function curveChemotherapyPharmacologyCancerBreast cancerBiologyBiotechnologyChemotherapy-induced cardiotoxicity and mitigationCardiac Ischemia and ReperfusionDiamond and Carbon-based Materials Research