Stepwise Tfh cell differentiation revisited: new advances and long-standing questions
Andrew R. Schroeder, Fangming Zhu, Hui Hu
Abstract
precursor Tfh (pre-Tfh) cells enter B cell follicles and differentiate further into germinal center Tfh (GC-Tfh) cells while others have a different fate. In this mini-review, we summarize the recent advances surrounding these two aspects of Tfh cell differentiation and discuss related long-standing questions, including Tfh memory.
Topics & Concepts
Germinal centerCXCR5Cellular differentiationAffinity maturationBiologyCellCell biologyB cellImmunologyAntibodyGeneticsGeneT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses