Generation of Human Embryonic Stem Cell-Derived Lung Organoids for Modeling Infection and Replication Differences between Human Adenovirus Types 3 and 55 and Evaluating Potential Antiviral Drugs
Shanshan Zhao, Xiaowei Wu, Zhihong Tan, Yi Ren, Lian Li, Junxian Ou, Ying Lin, Hongbin Song, Liqiang Feng, Donald Seto, Jianguo Wu, Qiwei Zhang, Zhili Rong
Abstract
Human adenovirus (HAdV) infections are a major threat worldwide. HAdV-3 is one of the most predominant respiratory pathogen types found in children.
Topics & Concepts
BiologyEmbryonic stem cellOrganoidStem cellVirologyViral replicationReplication (statistics)Antiviral drugCell biologyImmunologyComputational biologyVirusGeneticsGeneViral gastroenteritis research and epidemiologyVirus-based gene therapy researchBiomedical and Engineering Education