In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control
Pauline Trémeaux, Frédéric Lemoine, Adeline Mélard, Marine Gousset, Faroudy Boufassa, Sylvie Orr, Valérie Monceaux, Olivier Gascuel, Olivier Lambotte, Laurent Hocqueloux, Asier Sáez‐Cirión, Christine Rouzioux, Véronique Avettand-Fènoël, Faroudy Boufassa, Sylvie Orr, Firouzé Bani‐Sadr, Maxime Hentzien, Jean‐Luc Berger, I Kmiec, Gilles Pichancourt, Safa Nasri, Gilles Hittinger, Véronique Lambry, Anne-Cécile Beaudrey, Gilles Pialoux, Julie Chas, Christia Palacios, Anne Adda, Jean Paul Viard, Marie-Josée Dulucq, Laurence Weiss, Marina Karmochkine, Mohamed Meghadecha, Dominique Salmon‐Céron, Marie‐Pierre Pietri, P. Blanche, Jean‐Michel Molina, Olivier Tauléra, Diane Ponscarme, Jeannine Delgado Bertaut, Djamila Makhloufi, Matthieu Godinot, Valérie Artizzu, Patrick Miailhes, Laurent Cotte, Sophie Pailhes, Anne Conrad, L. Karkowski, Stanislas Ogoudjobi, Yazdan Yazdanpanah, Sophie Matheron, Cindy Godard, Louis Bernard, Frédéric Bastides, Olivier Bourgault, Christine Jacomet, Émilie Goncalves, P. Chavanet, Lionel Piroth, Sandrine Gohier, Agnès Meybeck, Thomas Huleux, Pauline Cornavin, Yasmine Debab, David Théron, Thiérry Prazuck, Laurent Hocqueloux, Barbara De Dieuleveult, J Faller, Patricia Eglinger, P. Roblot, David Plainchamp, Hugues Aumaître, Martine Malet, Christine Rouger, Gérard Rémy, Melle Kmiec Isabelle, J.-L. Delassus, Alain Devidas, Eric Froguel, Sylvie Tassi, Philippe Genet, Juliette Gerbe, O. Patey, Laurent Richier, Marie-Christine Drobacheff, Aurélie Proust, H. Gil, Laurence Gérard, Éric Oksenhendler, Jean‐Michel Molina, C. Lascoux, S Parlier, F. Lucht, Véronique Ronat, M. Dupon, Hervé Dutronc, Séverine Le Puil, D. Neau, P. Mercié
Abstract
Most people living with HIV need antiretroviral therapy to control their infection and experience viral relapse in case of treatment interruption, because of viral reservoir (proviruses) persistence. Knowing that proviruses are very diverse and most of them are defective in treated individuals, we aimed to characterize the HIV blood reservoirs of posttreatment controllers (PTCs), rare models of drug-free remission, in comparison with spontaneous controllers and treated individuals.