Copper-catalyzed radical cascade cyclization for synthesis of CF₃-containing tetracyclic benzimidazo[2,1-<i>a</i>]iso-quinolin-6(5<i>H</i>)-ones

Abstract

Here, a general copper-catalyzed radical cascade carbocyclization reaction with 2-arylbenzoimidazoles and a Togni reagent was realized. Structurally diverse CF3-containing tetracyclic core benzimidazo[2,1-a]isoquinoline-6(5H)-ones were obtained in moderate to good yields. The wide substrate scope, good functional group tolerance, and ease of scale-up of this method are expected to promote its potential applications in pharmacy and biotechnology.

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