Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp<sup>3</sup> C–H Functionalization
Xiangjin Zhang, Zhuo Wang, Han Zhang, Jingjing Gao, Kairui Yang, Wei-Yu Fan, Ruixue Wu, Meng-Lin Feng, Wei Zhu, Yanping Zhu
Abstract
An efficient method for the synthesis of new indolizine-fused chromones has been accomplished from ethyl (E)-3-(2-acetylphenoxy)acrylates and pyridines in a “one-pot” manner. Facile operation in open-air, metal-free, and mild conditions renders this protocol particularly practical and attractive. Moreover, this method can simultaneously construct two molecular fragments of chromone and indolizine. Scale-up experiment and the construction of natural products further prove the practicability of this strategy.
Topics & Concepts
IndolizineChemistryChromoneDominoIodineCombinatorial chemistrySurface modificationCascade reactionOrganic chemistryCatalysisPhysical chemistrySynthesis and Reactivity of HeterocyclesCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms