Mutant Huntingtin Impairs Pancreatic β-cells by Recruiting IRS-2 and Disturbing the PI3K/AKT/FoxO1 Signaling Pathway in Huntington’s Disease
Li Li, Yun Sun, Yinong Zhang, Weixi Wang, Cuifang Ye
Topics & Concepts
FOXO1Protein kinase BPI3K/AKT/mTOR pathwayHuntingtinBiologySignal transductionInsulin receptorCell biologyProto-Oncogene Proteins c-aktPhosphorylationCancer researchInsulinEndocrinologyInsulin resistanceBiochemistryMutantGeneGenetic Neurodegenerative DiseasesPancreatic function and diabetesEndoplasmic Reticulum Stress and Disease