Synthesis of Novel Furo[3,2‐c]coumarin Derivatives through Multicomponent [4+1] Cycloaddition Reaction Using ZnO/FAp as a Sustainable Catalyst
Nagaraju Kerru, Lalitha Gummidi, Kranthi Kumar Gangu, Suresh Maddila, Sreekantha B. Jonnalagadda
Abstract
Abstract An efficient green protocol is developed for the synthesis of ten new furo[3,2‐c]coumarin derivatives employing zinc oxide loaded on fluorapatite (ZnO/FAp) as catalyst. The three‐component one‐pot condensation occurs between the 4‐hydroxycoumarin, isocyanide and selected aldehyde in ethanol solvent at room temperature. Excellent yields (94‐98 %) of target products in 16‐20 min reaction time is the attractive feature. As‐synthesized catalysts and organic compounds were fully established by powder‐XRD, TEM, SEM, EDX, FT‐IR, BET, HRMS, 1 H NMR and 13 C NMR analysis. The catalyst is recyclable up to five times with high efficacy and marginal loss of activity. The reaction facilitated 98 % of the atom economy and 100 % carbon efficiency. Other advantages of the protocol are mild reaction conditions, easy‐workup, green solvent, catalyst reusability, and chromatography free products.