c-Jun/c-Fos complex in laryngeal squamous cell carcinoma.
Evangelos Tsiambas, Nicholas Mastronikolis, Panagiotis P Fotiades, Efthymios Kyrodimos, Aristeidis Chrysovergis, Vasileios Papanikolaou, Stylianos Mastronikolis, Dimitrios Peschos, Dimitrios Roukas, Vasileios Ragos
Abstract
During laryngeal carcinogenesis, a variety of genomic imbalances are involved in hyperplastic and dysplastic laryngeal epithelia as early or progressive genetic events, respectively. Oncogenes' overactivation is a crucial genetic event in malignant and pre-malignant neoplastic epithelia. Especially, deregulation of crucial pathways including transcription factors - such as c-Fos and c-Jun - leads to an aberrant expression of other crucial genes responsible for cell homeostasis. Upregulation of c-Fos and c-Jun proto-oncogenes -due to increased copy numbers (amplification) or intra-genic point mutations- seems to be correlated with aggressive biological behaviour in laryngeal squamous cell carcinomas (LSCCs). In the current special molecular article we explored the role of c-Fos/c-Jun complex deregulation in LSCC.