Shear stress activates the Piezo1 channel to facilitate valvular endothelium-oriented differentiation and maturation of human induced pluripotent stem cells
Minghui Xie, Hong Cao, Weihua Qiao, Ge Yan, Xingyu Qian, Yecen Zhang, Xu Li, Shuyu Wen, Jiawei Shi, Min Cheng, Nianguo Dong
Topics & Concepts
PIEZO1Induced pluripotent stem cellCell biologyShear stressStem cellProtein kinase BEndothelial stem cellPI3K/AKT/mTOR pathwayMaterials scienceBiologyChemistrySignal transductionInternal medicineMedicineReceptorIon channelMechanosensitive channelsBiochemistryEmbryonic stem cellGeneIn vitroComposite materialErythrocyte Function and PathophysiologyPancreatic function and diabetesHippo pathway signaling and YAP/TAZ