Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice
Wassihun Wedajo Aragaw, Christine Roubert, Evelyne Fontaine, Sophie Lagrange, Matthew D. Zimmerman, Véronique Dartois, Martin Gengenbacher, Thomas Dick
Abstract
and in a mouse model of infection. This adds a novel advanced lead compound to the M. abscessus drug pipeline and supports a strategy of screening chemical matter generated in TB drug discovery efforts to fast-track the discovery of novel antibiotics against M. abscessus.
Topics & Concepts
Mycobacterium abscessusNontuberculous mycobacteriaMycobacterium tuberculosisAntibioticsDrug discoveryMicrobiologyMycobacteriumMedicineDrugTuberculosisAntimycobacterialAntibacterial agentBiologyVirologyImmunologyBacterial proteinAntimicrobialDrug resistanceMycobacterium research and diagnosisTuberculosis Research and EpidemiologyQuinazolinone synthesis and applications