Impact of Diabetes on the Gut and Salivary IgA Microbiomes
Eric L. Brown, Heather T. Essigmann, Kristi L. Hoffman, Noah W. Palm, Sarah M. Gunter, Joel M. Sederstrom, Joseph F. Petrosino, Goo Jun, David Aguilar, William B. Perkison, Craig L. Hanis, Herbert L. DuPont
Abstract
= 8/group). These analyses demonstrated shifts in relative abundance in the IgA-Biome profiles between normoglycemic, prediabetic, or diabetic samples distinct from that of the overall microbiome. Differences in IgA-Biome alpha diversity were apparent for both stool and saliva, while overarching bacterial community differences (beta diversity) were also observed in saliva. These data suggest that IgA-Biome analyses can be used to identify novel microbial signatures associated with diabetes and support the need for further studies exploring these communities. Ultimately, an understanding of the IgA-Biome may promote the development of novel strategies to restructure the microbiome as a means of preventing or treating diseases associated with dysbiosis at mucosal surfaces.