<i>N</i>-Aminoacyl-3-amino-<i>nido</i>-carboranes as a Group of Boron-Containing Derivatives of Natural Amino Acids
Dmitry А. Gruzdev, Angelina A. Telegina, Галина Л. Левит, В. П. Краснов
Abstract
A new group of nido-carboranyl derivatives of natural (S)-amino acids containing from 9 to 18 boron atoms was obtained in good yields as a result of acylation of 3-amino-1,2-dicarba-closo-dodecaborane followed by deboronation. The proposed approach is convenient and based on the use of readily available reagents and is suitable for the synthesis of enantiopure nido-carboranyl derivatives of amino acids with various side chains, including water-soluble boron-containing amino acids (17 examples).
Topics & Concepts
ChemistryBoronAmino acidAcylationReagentEnantiopure drugCarboraneGroup (periodic table)Organic chemistryCombinatorial chemistryBiochemistryCatalysisEnantioselective synthesisBoron Compounds in ChemistryRadiopharmaceutical Chemistry and ApplicationsBone health and treatments