Immunocompetent mouse models revealed that S100A4 <sup>+</sup> monocytes/macrophages facilitate long-term Zika virus infection in the testes
Wei Yang, Chen Zhang, Libo Liu, Zhan-Zhan Bian, Jia-Tong Chang, Dongying Fan, Na Gao, Peigang Wang, Jing An
Abstract
monocytes/macrophages had a great impact on the microenvironment of ZIKV-infected testes, thus promoting ZIKV-induced testicular lesions. In conclusion, this study proposed a novel mechanism of long-term ZIKV infection in the male reproductive system.
Topics & Concepts
Zika virusViremiaVirologyBiologyImmunologyPopulationVirusMedicineEnvironmental healthMosquito-borne diseases and controlViral Infections and VectorsCOVID-19 Impact on Reproduction