High-Density and Large-Scale MEA System Featuring 236,880 Electrodes at 11.72μm Pitch for Neuronal Network Analysis
Yuri Kato, Yoshihisa Matoba, Katsumi Honda, Koji Ogawa, Kan Shimizu, Masataka Maehara, Atsushi Fujiwara, Aoi Odawara, Chigusa Yamane, N. Kimizuka, Jun Ogi, Tadayuki Taura, Ikuro Suzuki, Yusuke Oike
Abstract
Microelectrode arrays (MEAs) allow us to observe electrical activities from neurons at multiple sites. This paper presents a high-density microelectrode array (HD-MEA) for observing neuronal networks at a cellular level, featuring 236,880 electrodes at an 11.72 μm pitch and 33,840 readout channels with a noise level of 5.5 μVrms. The Peltier cooling system is integrated to maintain the temperature of the electrodes at approximately 37 °C. Moreover, electrical signals for the axonal propagation of rat neurons are successfully recorded.
Topics & Concepts
ElectrodeScale (ratio)Materials scienceComputer scienceOptoelectronicsElectrical engineeringPhysicsEngineeringQuantum mechanicsNeuroscience and Neural EngineeringNeural dynamics and brain functionElectrochemical Analysis and Applications