A Multiplexed Barcodelet Single-Cell RNA-Seq Approach Elucidates Combinatorial Signaling Pathways that Drive ESC Differentiation
Grace Hui Ting Yeo, Lin Lin, Celine Yueyue Qi, Minsun Cha, David K. Gifford, Richard I. Sherwood
Topics & Concepts
BiologyEmbryonic stem cellComputational biologyCellular differentiationCell fate determinationSignal transductionGastrulationStem cellCell biologyGerm layerNodal signalingCellNotochordGene regulatory networkGeneGene expressionGeneticsTranscription factorInduced pluripotent stem cellEmbryogenesisSingle-cell and spatial transcriptomicsCRISPR and Genetic EngineeringPluripotent Stem Cells Research