cGMP signaling pathway that modulates NF-κB activation in innate immune responses
Hirotaka Kanoh, Shinzo Iwashita, Takayuki Kuraishi, Akira Gotō, Naoyuki Fuse, Haruna Ueno, Mariko Nimura, Tomohito Oyama, Chang Tang, Ryo Watanabe, Aki Hori, Yoshiki Momiuchi, Hiroki Ishikawa, Hiroaki Suzuki, Kumiko Nabe, Takeshi Takagaki, Masataka Fukuzaki, Lili Tong, Sinya Yamada, Yoshiteru Oshima, Toshiro Aigaki, Julian A. T. Dow, Shireen-Anne Davies, Shoichiro Kurata
Abstract
. A membrane-bound cGK, PRKG2, also modulates NF-κB activation via PP2A in human cells, indicating that modulation of NF-κB activation in innate immunity by the cGMP signaling pathway is evolutionarily conserved.
Topics & Concepts
Cell biologyInnate immune systemSignal transductionBiologyClassical complement pathwayNF-κBIκB kinaseReceptorImmune systemBiochemistryComplement systemImmunologyInvertebrate Immune Response MechanismsBioactive Compounds and Antitumor AgentsAquaculture disease management and microbiota