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Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness

Qiaoyi Hua, Xin Meng, Xin Meng, Chen Wu, Yifan Xu, Ruiwei Xu, Yunxiu Shi, Jiajianghui Li, Xueling Meng, Xueling Meng, Ailin Li, Qianqian Chai, Mengshuang Sheng, Yuan Yao, Yunfei Fan, Ruohong Qiao, Yi Zhang, Teng Wang, Yidan Zhang, Xiaoyu Cui, Yaqi Yu, Haonan Li, Rui Tang, Meilin Yan, Duo Bu, Dunzhu Danzeng, Zhuo Ga, Lei Hou, Yingjun Liu, Jing Shang, Quan Chen, Xinghua Qiu, Chunxiang Ye, Jicheng Gong, Tong Zhu

2025Journal of the American College of Cardiology19 citationsDOIOpen Access PDF

Abstract

BACKGROUND: exposure may induce changes in hypoxia-related markers, leading to adverse cardiovascular effects. OBJECTIVES: exposure with hypoxic biomarkers and arterial stiffness. METHODS: in 2-pollutant models. RESULTS: with hypoxic biomarkers varied by altitude. The higher altitude group showed delayed associations with SpO₂ and HIF-1 expression but stronger associations with RBC indices. These associations remained robust after adjusting for copollutants. CONCLUSIONS: -induced cardiovascular injury.

Topics & Concepts

MedicineArterial stiffnessHypoxia (environmental)CardiologyTerm (time)Internal medicineOxygenBlood pressurePhysicsOrganic chemistryChemistryQuantum mechanicsMedical and Biological Ozone ResearchClimate Change and Health ImpactsCardiovascular Health and Disease Prevention
Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness | Litcius