Diversity in EWAS: current state, challenges, and solutions
Charles E. Breeze, Jason Y.Y. Wong, Stephan Beck, Sonja I. Berndt, Nora Franceschini
Abstract
Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis.
Topics & Concepts
Human geneticsDiversity (politics)Current (fluid)Computational biologyState (computer science)ProteomicsComputer scienceMedicineData scienceBiologyGeneticsAnthropologyEngineeringSociologyAlgorithmGeneElectrical engineeringGenetically Modified Organisms ResearchEnergy and Environment ImpactsEnergy, Environment, Economic Growth