Construction of Boronated <i>γ</i>‐Lactams via Palladium‐Catalyzed Intramolecular Boryldifluoroalkylation of Alkenes
Wu‐Jie Lin, Yu‐Zhao Wang, Jian‐Yu Zou, Yichuan Zhao, Jinlin Wang, Xue‐Yuan Liu
Abstract
Abstract An approach for the preparation of boronated γ ‐lactams via palladium‐catalyzed boryldifluoroalkylation of alkenes with α ‐bromodifluoroacetamides was developed. This method exhibits good functional group tolerance. Various boronated products were obtained in moderate to good yields for 1 h. Mechanistic studies indicated that this reaction may involve an intramolecular radical cascade cyclization process. magnified image
Topics & Concepts
ChemistryIntramolecular forcePalladiumCatalysisCascadeFunctional groupCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryChromatographyPolymerFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions