Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study
Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi
Abstract
AIM: We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians. METHODS: ) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints. RESULTS: for obesity-related cancer was -0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women. CONCLUSION: is associated with an increased risk of obesity-related cancer in women and CVD in both sexes.