<i>Akkermansia muciniphila</i> and <i>Bifidobacterium bifidum</i> Prevent NAFLD by Regulating FXR Expression and Gut Microbiota
Fulin Nian, Longyun Wu, Qiaoyun Xia, Peiying Tian, Chunmei Ding, Xiaolan Lu
Abstract
Background and aims: could prevent NAFLD, the effects of their action alone or in combination, possible mechanisms, and modulation of the gut microbiota. Methods: Mice were fed with high-fat diets (HFD) for 20 weeks, in which experimental groups were pretreated with quadruple antibiotics and then given the corresponding bacterial solution or PBS. The expression of the glycolipid metabolism indicators, liver, and intestinal farnesol X receptors (FXR), and intestinal mucosal tight junction proteins were detected. We also analyzed the alterations of inflammatory and immune status and the gut microbiota of mice. Results: <0.05). We also perceived changes in the gut microbiota and found both strains were able to synergize beneficial microbiota to function. Conclusions: alone or in combination was protective against HFD-induced NAFLD formation and could be used as alternative treatment strategy for NAFLD after further exploration.