Design, synthesis, and evaluation of formylpiperazine analogs of Ferrostatin-1 as novel improved ferroptosis inhibitors
Hua‐Long Ji, Yifan Zhang, Nai-Yu Zhang, Kaiming Wang, Ning Meng, Juan Zhang, Cheng‐Shi Jiang, Juan Zhang, Cheng‐Shi Jiang
Topics & Concepts
ChemistryUmbilical veinGPX4Reactive oxygen speciesCytotoxicityApoptosisLipid peroxidationDownregulation and upregulationBiochemistryProgrammed cell deathGlutathionePharmacologyOxidative stressIn vitroEnzymeGeneBiologyGlutathione peroxidaseFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer