Imaging-Guided Chemo–Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor
Zeyu Li, Jiatong Ni, Liping Liu, Liyuan Gu, Zhiguang Wu, Tianlong Li, Krasnyuk Ivan Ivanovich, Wancheng Zhao, Tiedong Sun, Ting Wang
Abstract
We demonstrate a versatile nanoparticle with imaging-guided chemo–photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo–photothermal synergistic therapy toward liver cancers in the near future.