Effect of pH-sensitive nanoparticles on inhibiting oral biofilms
Xinyu Peng, Qi Han, Xuedong Zhou, Yanyan Chen, Xiaoyu Huang, Xiao Guo, Ruiting Peng, Haohao Wang, Xian Peng, Lei Cheng
Abstract
biofilms. In addition, it had no effect on eradicating healthy saliva-derived biofilm, while free CHX exhibited an inhibitory effect. Furthermore, the 16s rDNA sequencing results showed that p(DH)@CHX had the potential to alter oral microbiota composition and possibly reduce caries risk. In conclusion, the present study presents an alternative option to design an intelligent material to prevent and treat dental caries.
Topics & Concepts
BiofilmChlorhexidineStreptococcus mutansSalivaMicrobiologyChemistryIn vitroCytotoxicityBacteriaDental plaqueAntimicrobialMinimum inhibitory concentrationDentistryPharmacologyMedicineBiologyBiochemistryGeneticsOral microbiology and periodontitis researchHIV/AIDS oral health manifestationsDental Health and Care Utilization