Emerging Diagnostic Potential of Tumor-derived Exosomes
Ruhua Luo, Mengmeng Liu, Qian Yang, Huijuan Cheng, Huimin Yang, M Li, Xue Bai, Yue Wang, Honghua Zhang, Shuling Wang, Tian Xie, Qingchang Tian
Abstract
Exosomes carry genetic information originating from their parental cells, raising their possibility as novel noninvasive biomarkers for cancer. Tumor-derived exosomes (TEXs) have a variety of endogenous cargos that reflect the pathophysiology status and information of tumor cells. TEXs are increasingly being recognized as potential biomarkers for cancer diagnosis prognosis, and monitoring. It is important to develop a variety of sensitive methods, including probes and biomaterials to isolate exosomes. A variety of approaches for detecting exosomes have been established. By combining exosome DNA and RNA sequencing tools, exosome proteomics analysis and immunoassay technology, it is expected that exosomes will gain widespread use in the diagnosis and treatment of cancer.