Dual roles of fucoidan-GPIbα interaction in thrombosis and hemostasis: implications for drug development targeting GPIbα
Chuanbin Shen, Daniel Thomas MacKeigan, Aron A. Shoara, Runjia Xu, Preeti Bhoria, Danielle Karakas, Wenjing Ma, Eric G. Cerenzia, ZiYan Chen, Brock Hoard, Lisha Lin, Xi Lei, Guangheng Zhu, Pingguo Chen, Philip E. Johnson, Heyu Ni
Topics & Concepts
FucoidanChemistryVon Willebrand factorPlatelet activationPlateletPlatelet membrane glycoproteinThrombusDisintegrinHemostasisBiochemistryPlatelet Glycoprotein GPIb-IX ComplexPharmacologyImmunologyReceptorMedicineInternal medicineEnzymePolysaccharideMetalloproteinaseSeaweed-derived Bioactive CompoundsPlatelet Disorders and TreatmentsEnzyme Production and Characterization