Integration of molecular profiles in a longitudinal wellness profiling cohort
Abdellah Tebani, Anders Gummesson, Wen Zhong, Ina Schuppe‐Koistinen, Tadepally Lakshmikanth, Lisa Olsson, Fredrik Boulund, Maja Neiman, Hans Stenlund, Cecilia Hellström, Max Karlsson, Muhammad Arif, Tea Dodig‐Crnković, Adil Mardinoğlu, Sunjae Lee, Cheng Zhang, Yang Chen, Axel Olin, Jaromír Mikeš, Hanna Danielsson, Kalle von Feilitzen, Per-Anders Jansson, Oskar Angerås, Mikael Huss, Sanela Kjellqvist, Jacob Odeberg, Fredrik Edfors, Valentina Tremaroli, Björn Forsström, Jochen M. Schwenk, Peter Nilsson, Thomas Möritz, Fredrik Bäckhed, Lars Engstrand, Petter Brodin, Göran Bergström, Mathias Uhlén, Linn Fagerberg
Abstract
An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.