Decreased expression of TRPM4 is associated with unfavorable prognosis and aggressive progression of endometrial carcinoma.
Xing-Chen Li, Yuan Cheng, Xiao Yang, Jingyi Zhou, Yangyang Dong, Boqiang Shen, Jiaqi Wang, Lijun Zhao, Zhiqi Wang, Xiaoping Li, Jianliu Wang
Abstract
. Overall, these results indicate that TRPM4 is clinically useful in predicting EC prognosis and represent a potential candidate as a new therapeutic target.
Topics & Concepts
Endometrial cancerCancer researchGene silencingProportional hazards modelTransient receptor potential channelInternal medicineMedicinePI3K/AKT/mTOR pathwayIntracellularSuppressorBiologyGeneOncologyCancerReceptorSignal transductionCell biologyGeneticsMicroRNA in disease regulationIon Channels and ReceptorsSeaweed-derived Bioactive Compounds