Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling
Mohammed Hawash, Samer Abdallah, Mahmoud Abudayyak, Yarob Melhem, Mohammed Abu Shamat, Meera Aghbar, İrfan Çapan, Murad Abualhasan, Anil Kumar, Michał Kamiński, Tomasz Góral, P.M. Dominiak, Shorooq Sobuh
Topics & Concepts
HeLaChemistryIC50StereochemistryIsoxazoleApoptosisDoxorubicinCytotoxic T cellCancer cellBiochemistryCancerIn vitroBiologyGeneticsChemotherapySynthesis and biological activityEnzyme function and inhibitionBioactive Compounds and Antitumor Agents