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Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

Peng Li, Ying Liu, Hua Yang, Hong-Min Liu

2021European Journal of Medicinal Chemistry29 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCell growthMTT assayCancer cellDocking (animal)CarcinogenesisCancerDeubiquitinating enzymeIC50Cancer researchBiochemistryStereochemistryIn vitroUbiquitinBiologyGeneMedicineGeneticsNursingUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyHistone Deacetylase Inhibitors Research
Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors | Litcius