The Impact of Omega-3 Fatty Acids on the Evolution of Acinetobacter baumannii Drug Resistance
Maoge Zang, Felise G. Adams, Karl A. Hassan, Bart A. Eijkelkamp
Abstract
supplementation with host polyunsaturated fatty acids reduces the rate at which A. baumannii gains resistance to erythromycin and tetracycline. Furthermore, we discover that the impact on resistance development is closely associated with the primary antimicrobial efflux systems of A. baumannii, which represent one of the major drivers of clinical resistance. Overall, this study emphasizes the potential of host macromolecules in novel approaches to circumvent the difficulties of multidrug resistance during A. baumannii treatment, with fatty acid supplements such as fish oil providing safe and cost-effective ways to enhance host tolerance to bacterial infections.
Topics & Concepts
BiologyAcinetobacter baumanniiAntibiotic resistanceDrug resistanceAntibioticsMultiple drug resistanceMicrobiologyPathogenPolyunsaturated fatty acidEffluxDocosahexaenoic acidFatty acidGeneticsBacteriaBiochemistryPseudomonas aeruginosaAntibiotic Resistance in BacteriaVibrio bacteria research studiesGenomics and Phylogenetic Studies