Mathematical Modeling of the Gut–Bone Axis and Implications of Butyrate Treatment on Osteoimmunology
Mohammad Aminul Islam, Carley V. Cook, Brenda J. Smith, Ashlee N. Ford Versypt
Abstract
and CD8+ T cell-derived Wnt-10b with changes in gut butyrate concentration. In addition, we connect our model to a detailed model of bone metabolism to study the impacts of butyrate and Wnt-10b on trabecular bone volume. Our results indicate both direct and indirect immune-mediated impacts of butyrate on bone metabolism.
Topics & Concepts
ButyrateOsteoimmunologyWnt signaling pathwayCell biologyBone remodelingGut floraImmune systemChemistryMetabolismBiologyImmunologyBiochemistryEndocrinologySignal transductionRANKLActivator (genetics)GeneFermentationGut microbiota and healthImmune cells in cancerImmune Response and Inflammation