ncRNA-mediated ceRNA regulatory network: Transcriptomic insights into breast cancer progression and treatment strategies
Shu Yang, Xiaomin Wang, Xintong Zhou, Lin Hou, Jibiao Wu, Wenfeng Zhang, Huayao Li, Chundi Gao, Changgang Sun
Abstract
With the rapid development of next-generation sequencing technology, several studies have shown that ncRNAs can act as competitive endogenous RNAs (ceRNAs) and are involved in various biological processes, such as proliferation, differentiation, apoptosis, and migration of breast cancer (BC) cells, and plays an important role in BC progression as a molecular target for its diagnosis, treatment, prognosis, and differentiation of subtypes and age groups of BC patients. Based on the description of ceRNA-related biological functions, this study screened and sorted the sequencing analysis and experimental verification conclusions of BC-related ceRNAs and found that the ncRNAs mediated ceRNA networks can promote the development of BC by promoting the expression of genes related to BC proliferation, drug resistance, and apoptosis, inducing the production of epithelial-mesenchymal transition (EMT) to promote metastasis and activating cancer-related signaling pathways. • ncRNA-mediated ceRNA networks is involved in various biological processes of breast cancer. • ncRNA-mediated ceRNA networks play a crucial role in diagnosis of breast cancer. • ncRNA-mediated ceRNA networks may facilitate the development of new anti-tumor drugs and clinical interventions of breast cancer.