Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes
Lloyd Wei Tat Tang, Ethan DaSilva, Kimberly Lapham, R. Scott Obach
Topics & Concepts
Aldehyde oxidasePharmacologyErlotinibIn vivoMicrosomeAldehyde dehydrogenaseChemistryEnzymeCytochrome P450Drug metabolismBiochemistryBiologyXanthine oxidaseEpidermal growth factor receptorBiotechnologyReceptorPharmacogenetics and Drug MetabolismEicosanoids and Hypertension PharmacologyMicrobial Metabolic Engineering and Bioproduction