Drebrin regulates cytoskeleton dynamics in migrating neurons through interaction with CXCR4
Yufei Shan, Stephen M. Farmer, Susan Wray
Abstract
Significance Proper neuronal migration is critical for the formation of correct neural circuits during development. Chemokines are known to facilitate neuronal migration. However, the underlying mechanism is still unclear. Here, we reveal a novel mechanism whereby the chemokine receptor (CXCR4), after being activated by its ligand, SDF-1, interacts directly with the cytoskeleton compartment via drebrin, an actin-binding protein that interacts with microtubule plus-end–binding proteins. The interaction between activated CXCR4/drebrin promotes neuronal migration. The study provides insights on the relationship between extracellular cues and intracellular components.
Topics & Concepts
Cell biologyCytoskeletonActin cytoskeletonDendritic spineHippocampal formationReceptorColocalizationIntracellularBiologyChemistryNeuroscienceCellBiochemistryNeurogenesis and neuroplasticity mechanismsCell Adhesion Molecules ResearchAxon Guidance and Neuronal Signaling