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Divergent synthesis of functionalized indazole <i>N</i>-oxides with anticancer activity <i>via</i> the cascade reaction of <i>N</i>-nitrosoanilines with diazo compounds and HFIP

Yuqian Sun, Shengnan Yan, Kelin Wang, Bin Li, Chunhua Ma, Xinying Zhang, Xuesen Fan

2025Organic Chemistry Frontiers28 citationsDOI

Abstract

Presented herein is a novel divergent synthesis of indazole N -oxides based on the one-pot cascade reaction of N -nitrosoanilines with diazo compounds and HFIP.

Topics & Concepts

IndazoleChemistryDiazoCascadeCombinatorial chemistryCascade reactionStereochemistryMedicinal chemistryOrganic chemistryCatalysisChromatographySynthesis and Biological Evaluation
Divergent synthesis of functionalized indazole <i>N</i>-oxides with anticancer activity <i>via</i> the cascade reaction of <i>N</i>-nitrosoanilines with diazo compounds and HFIP | Litcius