Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection
Xian Tang, Shuye Zhang, Qiaoli Peng, L. Ling, Huichun Shi, Y. Liu, Lin Cheng, Lingqing Xu, Lin Cheng, Lisa A. Chakrabarti, Zhiwei Chen, Hui Wang, Zheng Zhang
Abstract
responses of MAIT cells from HIV-1-infected patients. Our findings demonstrate the central role of the IFN-I/IL-10 axis in MAIT cell dysfunction during HIV-1 infection, which has implications for the development of anti-IFN-I/IL-10 strategies against bacterial coinfections in HIV-1-infected patients.
Topics & Concepts
StimulationHuman immunodeficiency virus (HIV)ImmunologyBacteriaMedicineChronic infectionBiologyMicrobiologyImmune systemInternal medicineGeneticsImmune Cell Function and InteractionCytomegalovirus and herpesvirus researchImmunotherapy and Immune Responses