The role of biomaterials-based scaffolds in advancing skin tissue construct
Komal Sindhi, Ravindra Babu Pingili, Vishal Beldar, Sankha Bhattacharya, Jiyaur Rahaman, Dhrubojyoti Mukherjee
Abstract
Despite extensive clinical studies and therapeutic interventions, addressing significant skin wounds remains challenging, necessitating novel approaches for effective regeneration therapy. In the current review, we analyzed and evaluated the application, advancements, and future directions of biomaterials-based scaffolds for skin tissue construct. In addition, we investigated the role of other biological substitutes in promoting wound healing and skin tissue regeneration. The review highlights the impact of biomaterial-based scaffolds on skin tissue regeneration and wound healing. After presenting the physiological process of skin tissue regeneration, the review emphasizes the different biochemical components significant for skin healing and regeneration. Subsequently, it delves into the role of scaffolds in skin tissue engineering. Recent advancements in nanotechnology are also highlighted with a specific focus on the utilization of nanomaterials for enhancing healing, facilitating tissue regeneration, and promoting skin reconstruction. Biomaterial scaffolds have emerged as a potential intervention for wound healing forming the foundation of skin tissue regeneration. These scaffolds, intricate three-dimensional frameworks, serve as carriers for cells, medications, and genes, facilitating their delivery into the body. The integration of degradable porous scaffolds with biological cells offers a promising avenue for tissue repair. Biomaterials play a crucial role in tissue engineering, providing temporary mechanical support and facilitating cellular processes to augment skin tissue regeneration. • Despite extensive clinical studies and therapeutic interventions, addressing significant skin wounds remains challenging. • Biomaterial scaffolds have emerged as a potential intervention for wound healing forming the foundation of skin tissue regeneration. • Different signaling molecules, cells, stem cells, and biomaterials explored within tissue engineering represent a transformative approach for tissue regeneration strategies. • The integration of degradable porous scaffolds with biological cells offers a promising avenue for tissue repair. • Utilization of biomaterial-based scaffolds holds tremendous potential in revolutionizing skin tissue regenerative strategies.