Differential Virulence of Aggregatibacter actinomycetemcomitans Serotypes Explained by Exoproteome Heterogeneity
Yanyan Fu, Sandra Maaβ, Francis M. Cavallo, Anne de Jong, Erwin C. Raangs, Johanna Westra, Girbe Buist, Dörte Becher, Jan Maarten van Dijl
Abstract
Periodontitis is an inflammatory disease that causes progressive destruction of alveolar bone and supporting tissues around the teeth, ultimately resulting in tooth loss. The bacterium Aggregatibacter actinomycetemcomitans ( Aa ) is a prevalent causative agent of periodontitis, but this oral pathogen is also associated with serious extraoral diseases like rheumatoid arthritis and Alzheimer’s disease.
Topics & Concepts
VirulenceSerotypeMicrobiologyAggregatibacter actinomycetemcomitansBiologyActinobacillusPathogenVirologyBacteriaGenePorphyromonas gingivalisGeneticsOral microbiology and periodontitis researchInfective Endocarditis Diagnosis and ManagementStreptococcal Infections and Treatments