Ruthenium‐Catalyzed Remote Difunctionalization of Nonactivated Alkenes for Double <i>meta</i>‐C(sp<sup>2</sup>)−H/C‐6(sp<sup>3</sup>)−H Functionalization
Shan Chen, Binbin Yuan, Yulei Wang, Lutz Ackermann
Abstract
Abstract Twofold distal C−H functionalization was accomplished by difunctionalization of nonactivated alkenes to provide rapid access to multifunctionalized molecules. The multicomponent ruthenium‐catalyzed remote 1, n ‐difunctionalization ( n =6,7) of nonactivated alkenes with fluoroalkyl halides and heteroarenes in a modular manner is reported. The meta ‐C(sp 2 )−H/C‐6(sp 3 )−H distal functionalization featured mild conditions, unique selectivity, and broad substrate scope with a domino process for twofold remote C(sp 2 )−H/C(sp 3 )−H activation of the sequential formation of three different carbon‐centered radicals. A plausible mechanism was proposed based on detailed experimental and computational studies.