Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway
Phil B. Alper, Jonathan A. Deane, Claudia Betschart, David Buffet, Géraldine Zipfel, Perry Gordon, Janice Hampton, Stuart Hawtin, Maureen Ibanez, Tao Jiang, Tobias Junt, Thomas Knoepfel, Bo Liu, Jillian Maginnis, Una McKeever, Pierre‐Yves Michellys, Daniel Mutnick, Bishnu P. Nayak, Satoru Niwa, Wendy Richmond, James S. Rush, Peter M. Syka, Yi Zhang, Xue‐Feng Zhu
Topics & Concepts
TLR7In vivoPharmacologyChemistryReceptorIn vitroPeripheral blood mononuclear cellPotencyBioavailabilityEx vivoToll-like receptorBiochemistryBiologyInnate immune systemBiotechnologyImmune Response and InflammationNF-κB Signaling PathwaysAntimicrobial Peptides and Activities