Two Catalytic Protocols for the Synthesis of CF<sub>2</sub>‐Containing Quinazolinones via Domino Reaction
Congyin Wei, Zhiyou Yu, Lei Shi
Abstract
Abstract Copper‐catalyzed and visible‐light catalytic difluoroalkylation reactions of N ‐cyanamide alkenes have been developed. Various α‐bromodifluoromethyl substituted esters, amides and heterocycles were employed as the CF 2 source. Both protocols are characterized by medium to high yields, good functional group compatibility, and applicable to gram‐scale synthesis. Comparable studies of copper catalysis and photoredox catalysis demonstrate minimal differences between the two protocols. Preliminary mechanism suggest that both transformations involve tandem radical cyclization process.
Topics & Concepts
ChemistryDominoCatalysisCascade reactionCombinatorial chemistryOrganic chemistryQuinazolinone synthesis and applicationsMicrowave-Assisted Synthesis and ApplicationsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry